Biomarker Discovery Program
Animal Model Development Program
Mouse models are important pre clinical testing tools for validating novel therapies and provide unique insights into pathogenesis of several diseases. During the last six years, we have developed the laser injury mouse model,NMDA induced Glaucoma model, Middle cerebral artery occlusion model and the Morris Water Maze Mouse model for testing novel molecules, extracts and biotherapeutics using invitro, invivo and pharmacological tools. Another major goal of the lab is to understand the triggers that stem cells exploit in rescuing the function in these models thereby providing new targets for drug discovery.
Manipulation of Neural and Retinal Stem Cells
We have established the primary human fetal cilliary epithelium cell cultures and formed neurospheres from these cells. The aim is to expolit their stem cell potential by elucidating the molecular pathway these cells follow in their differentiation into retinal neurons. Along with these cells, we have established primary mouse hippocampal cells for eventual transplantation into various mouse models already developed in our lab. In future, we would be exploiting these cell culture facilities and primary extracts for providing neurotoxicity testing services. We also plan to develop the electrophysiological facilities in order to understand the functional revival in our transplantation studies.
- CC chemokine receptor-3 as new target for age-related macular degeneration.
- Role of MCP-1 and Its Receptor in Age Related Macular Degeneration: Single Nucleotide Polymorphisms study
- Association between Expression of Chemokine Receptor-2 (CCR2) and Amyotrophic Lateral Sclerosis (ALS) Patients of North India.
- Amyotrophic lateral sclerosis (ALS) diagnosis: A predictive model
- A new marker for Neovascular Age-Related Macular Degeneration: Eotaxin-2
- Upregulation of chemokine ligand (CCL2) genes in peripheral blood mononuclear cells in amyotrophic lateral sclerosis.
- Levels of Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in Serum and CSF of Amyotrophic Lateral Sclerosis patients.
- The contribution of Vascular endothelial growth receptor (VEGF) and monocyte chemoattractant protein(MCP-1) to symptomatic atherosclerotic carotid plaques
- Elevated levels of Ccl-2 and VEGF in circulating lymphocytes of Indian sporadic ALS patients
- Diagnostic efficacy of Amplicor kit for detection of mycobacterium tuberculosis in the patients suspected of TBM
- Assessment of marrow derived stem cell implantation in experimentally induced brain stroke and retinal ischemia mouse model
- AMD mouse model: Mediation of macrophages
- Loss of mouse memory when exposed to rat predatory stress
- Stem cells repopulate the laser injured retina in mouse
- PARK 2 mutations cause Parkinsonism (PD) in Northwest Indian Patients
- Exploring memory enhancers: Brahmi reverses memory deficit